Safer Medicines - putting patient safety first

Putting patient safety first

Image Slider

Latest News

August 16, 2018

Predicting idiosyncratic drug-induced liver injury risk

New paper published in the journal Drug Metabolism and Disposition: Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?

Our Pharmaceutical Director, Dr Gerry Kenna co-authored the paper with Dr Jack Uetrecht, Professor of Pharmacy and Medicine at the University of Toronto and the Canada Research Chair in Adverse Drug Reactions

Many new medicines cause undesired side effects in humans that are not predicted by the drug safety studies performed currently. This review focuses on liver injury, which is an especially important human adverse drug effect. It highlights both the promising progress made in developing human-relevant in vitro methods that can anticipate and reduce drug induced liver injury risk, and outstanding challenges which remain to be addressed.


July 21, 2018

Dr Pandora Pound guest blogs for Animals in Science Policy Institute

Our Research Consultant, Dr Pandora Pound, gives a fascinating insight into the introduction of the use of systematic reviews in preclinical animal research, in which she played an instrumental role. 

Systematic reviews have become accepted as powerful tools that should be deployed routinely to improve the quality of the evidence base in clinical research. Although their use is not yet routine in preclinical research, they have been instrumental in provoking debate about the reliability, validity, and value of preclinical animal research. 

Read the article: The problem of evidence in pre-clinical animal research: how systematic reviews can help


May 02, 2018

Two brief newsletters with many items of interest

The second newsletter from the Alliance for Human Relevant Science is now published here

and the April newsletter from SYRCLE (SYstematic Review Center for Laboratory animal Experimentation) in the Netherlands is here


See more news here.

Share
Follow Us